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  2. PhD-student - Self-organization of human miniature hearts (cardiac organoids)

PhD-student - Self-organization of human miniature hearts (cardiac organoids)

Are you specialize in bioengineering, transcriptomics, proteomics and computational biology? Read below for more information.

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Key takeaways

  • Hours
    40 hr.
  • Salary indication
    Salary gross/monthly
    based on full-time
    € 2,541 - € 3,247
  • Deadline
    31 May 2023

The prospective PhD candidate will collaborate with team members who are specialized in bioengineering (Twente), transcriptomics, proteomics and computational biology (Nijmegen, Twente) as part of a recently awarded NWO OC-ENW-XL Consortium “HeartEngine”. The PhD candidate position is available immediately. In this project we will use innovative ultra-high throughput in-air-microfluidics for the generation of functional cardiac organoids that display self-organization and patterning, comparable to the human heart. As a member of the team, you will be involved in the generation of human pluripotent stem cell fluorescent reporter lines using CRISPR-Cas9 genome editing, differentiation of hPSC to multi-layered cardiac organoids using in-air-microfluidics. You will use high content imaging to study the self-organization and molecular regulation of cardiac organoids.

Your profile

  • You hold a master's degree in Biomedical Engineering, Materials Science, Biomedical Sciences, or an equivalent master's education;
  • You have excellent analytical skills and an innate ability for solution oriented problem solving.
  • You have experience in molecular biology, developmental biology, cell biology, or molecular life sciences is preferred.
  • You have experience in stem cell culture and techniques in molecular biology, such as Crispr-Cas9.
  • You have experience in one or more aspects of the project, for example stem cell differentiation, next generation sequencing, single-cell transcriptomics or proteomics.
  • You have strong interest in developmental biology, cardiovascular biology and/or tissue engineering.
  • You are excited about scientific discovery and would like to make a contribution to improved heart disease modelling
  • You possess excellent social and communication skills, in academic as well as non-academic contexts.
  • You love working in a team in which fundamental and applied research cross-fertilize.
  • You have a creative and critical attitude, combined with perseverance and being flexible and stress-resistant.
  • You are fluent in English language skills, both in speaking and writing.

Our offer

  • Fully paid fulltime position for four years
  • The university offers a dynamic ecosystem with enthusiastic colleagues in a stimulating scientific environment.
  • The PhD salary is € 2.541,- in the first year and increases to € 3.247,- in the fourth year.
  • A holiday allowance of 8% of the gross annual salary and a year-end bonus of 8.3%.
  • A solid pension scheme.
  • A professional and personal development program within Graduate School Twente.
  • The number of holiday hours for full-time employment is 232 hours per calendar year.
  • A personal development program within the Twente Graduate School.

Information and application

For questions about the position, please contact Robert Passier, Professor, at robert.passier@utwente.nl

Practical information and applying
You can apply until 31st of May 2023, exclusively using the button below. Kindly address your application to Robert Passier. Please fill in the application form and attach the following documents:

An interview and a scientific presentation will be part of the selection procedure.

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About the department

The PhD-candidates will work in the Passier Lab, which is part of the department of Applied Stem Cell Technologies AST. We use stem cell and molecular technologies, organ-on-chip-devices, advanced tissue engineering to emulate and understand organ development and function in health and disease. We AST is part of the Technical Medical Centre of the University of Twente, which is widely recognized for its cutting-edge developments in biomedical technology and advanced biomanufacturing.

About the organisation

The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

Want to know more?

Passier, P.C.J.J. (Robert)

Passier, P.C.J.J. (Robert)
Full Professor

Passier, P.C.J.J. (Robert)
Full Professor

Do you have questions about this vacancy? Then you can contact Robert for all substantive questions about this position and the application procedure. For general questions about working for the UT, please refer to the chatbot.

How to apply

Step 1

When you see a vacancy that appeals to you, you can apply online. We ask you to upload a CV and motivation letter and/or list of publications. You will receive a confirmation of receipt by e-mail.

Apply now

Step 2

The selection committee will review your application and you will receive a response within 2 weeks after the vacancy has been closed.

Step 3

1st interview.
The 1st (online or in person) meeting serves as an introduction where we introduce ourselves to you and you to us. You may be asked to give a short presentation. This will be further explained in the invitation.

Step 4

2nd interview.
In the second interview, we will further discuss the job content, your skills and your talents.

Step 5

The offer.
If the conversations are positive, you will be made a suitable offer.

Your Colleagues

About the TNW Faculty

Curious about what the Faculty of Science and Technology (TNW) stands for? Check out the Science and Technology website for more information.

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