Within the Clinical Neurophysiology group of the Institute of Technical Medicine we have available a PhD position for a project entitled:
Predicting Efficacy of Neuromodulation in Epilepsy (PREDYct)
In patients with medically refractory epilepsy vagus nerve stimulation and deep brain stimulation are possible treatment options. While effective in several patients, about 30-50% of patients do not respond favorably to this treatment.
This project aims to identify novel biomarkers to predict the success of vagus nerve stimulation (VNS) using ultra-long (up to more than a year) EEG measurements with a subcutaneous electrode (© UNEEG). This is complemented with (functional) MRI and high-density EEG recordings. Patients who are candidates for VNS will be implanted with the UNEEG device 2 months before implantation of the VNS. Treatment effects will be evaluated with the UNEEG electrode, complemented with diaries and questionnaires regarding epilepsy related symptoms. At present, nine patients have been implanted with the UNEEG electrode.
This project is a collaboration between the CNPH group of the University of Twente, the Neurocenter group (neurosurgery, neurology and clinical neurophysiology) of the Medisch Spectrum Twente and the epilepsy center SEIN in Zwolle.
This project is funded by the Dutch epilepsy foundation, EpilepsyNL.
Information and application
For more information, please contact: Prof.dr.ir M.J.A.M. van Putten, neurologist (firstname.lastname@example.org).
Please submit your application before October 03, including:
- A cover letter outlining your specific interest, qualifications, and motivation to apply for this position.
- A detailed CV including your list of publications, patents, and conferences.
- Transcripts from your Bachelor and Master degrees.
About the department
The clinical neurophysiology group is an interdisciplinary research group at the University focusing on translational research in epilepsy and cerebral ischaemia. The EEG is a key clinical and research tool. EEG signal analysis includes various machine learning techniques to improve diagnostic values and (bedside) application. Applied EEG studies are complemented by biophysical modeling and simulation for improved understanding of underlying neuronal dynamics and prediction of treatment effects. For more information, see our website
At the Neurocentrum of the Medisch Spectrum Twente neurologists, neurosurgeons, residents and technical physicians are involved in patient-care, education and research. Neuromodulation is a key expertise.
About the organization
The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.