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PhD Position: Predicting Efficacy of neuromodulation in epilepsy

PhD Position: Predicting Efficacy of neuromodulation in epilepsy

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Key takeaways

  • Hours 40 hr.
  • Salary indication € 2,541 - € 3,247
  • Deadline 3 Oct 2022

Within the Clinical Neurophysiology group of the Institute of Technical Medicine we have available a PhD position for a project entitled:

Predicting Efficacy of Neuromodulation in Epilepsy (PREDYct)

In patients with medically refractory epilepsy vagus nerve stimulation and deep brain stimulation are possible treatment options. While effective in several patients, about 30-50% of patients do not respond favorably to this treatment.

This project aims to identify novel biomarkers to predict the success of vagus nerve stimulation (VNS) using ultra-long (up to more than a year) EEG measurements with a subcutaneous electrode (© UNEEG). This is complemented with (functional) MRI and high-density EEG recordings.  Patients who are candidates for VNS will be implanted with the UNEEG device 2 months before implantation of the VNS.  Treatment effects will be evaluated with the UNEEG electrode, complemented with diaries and questionnaires regarding epilepsy related symptoms. At present, nine patients have been implanted with the UNEEG electrode.

This project is a collaboration between the CNPH group of the University of Twente, the Neurocenter group (neurosurgery, neurology and clinical neurophysiology) of the Medisch Spectrum Twente and the epilepsy center SEIN in Zwolle.

This project is funded by the Dutch epilepsy foundation, EpilepsyNL.

Your profile

  • We are looking for a highly motivated researcher with an MSc degree in Technical Medicine or Biomedical Engineering.
  • A very strong interest in clinical research, epilepsy, biomedical signal analysis and machine learning is essential.
  • Candidates need to have good organizing and social skills as he/she will be involved in patient recruitment, implantation of the UNEEG devices and measurements in the hospital.
  • Since communication with the patients is an essential part of this PhD position, speaking Dutch is preferred.
  • A strong background in signal analysis and machine learning is also required to work with the ultra-long and highly innovative data.
  • The candidate must like to work both in an hospital environment with patients medical specialists, as well as in the  interdisciplinary and internationally oriented environment of the university.
  • An interview and presentation will be part of the selection procedure.

Our offer

  • We offer a scientific education on a multidisciplinary subject. The assignment is for four years, with a go/no go assessment at the end of the first year.
  • Fulltime position for four years.
  • The university offers a dynamic ecosystem with enthusiastic colleagues in a stimulating scientific environment.
  • The PhD salary is € 2.541,- in the first year and increases to € 3.247,- in the fourth year.
  • A holiday allowance of 8% of the gross annual salary and a year-end bonus of 8.3%.
  • The number of holiday hours for full-time employment is 232 hours per calendar year.
  • A personal development program within the Twente Graduate School.

Information and application

For more information, please contact: Prof.dr.ir M.J.A.M. van Putten, neurologist (m.j.a.m.vanputten@utwente.nl).

Please submit your application before October 03, including:

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About the department

The clinical neurophysiology group is an interdisciplinary research group at the University focusing on translational research in epilepsy and cerebral ischaemia.  The EEG is a key clinical and research tool. EEG signal analysis includes various machine learning techniques to improve diagnostic values and (bedside) application. Applied EEG studies are complemented by biophysical modeling and simulation for improved understanding of underlying neuronal dynamics and prediction of treatment effects. For more information, see our website

At the Neurocentrum of the Medisch Spectrum Twente neurologists,  neurosurgeons, residents and technical physicians are involved in patient-care, education and research. Neuromodulation is a key expertise.

About the organization

The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

About the TNW Faculty

Curious about what the Faculty of Science and Technology (TNW) stands for? Check out the Science and Technology website for more information.

job that matters

Create new opportunities for yourself, your colleagues and our society. Scientist or teacher, administrator or facilitator, thinker or doer, energetic leader or silent support – your work at the University of Twente matters. And you too!

How to apply

Step 1

When you see a vacancy that appeals to you, you can apply online. We ask you to upload a CV and motivation letter and/or list of publications. You will receive a confirmation of receipt by e-mail.

Apply now

Step 2

The selection committee will review your application and you will receive a response within 2 weeks after the vacancy has been closed.

Step 3

1st interview.
The 1st (online or in person) meeting serves as an introduction where we introduce ourselves to you and you to us. You may be asked to give a short presentation. This will be further explained in the invitation.

Step 4

2nd interview.
In the second interview, we will further discuss the job content, your skills and your talents.

Step 5

The offer.
If the conversations are positive, you will be made a suitable offer.

Want to know more?

Putten, M.J.A.M. van (Michel)

Putten, M.J.A.M. van (Michel)
Full Professor

Putten, M.J.A.M. van (Michel)
Full Professor

Do you have questions about this vacancy? Then you can contact Michel for all substantive questions about this position and the application procedure. For general questions about working for the UT, please refer to the chatbot.

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