Faculty of Behavioral, Management and Social sciences (BMS). The focus at this faculty is on Psychology, Business Administration, Public Administration, Communication Sciences, Philosophy, Educational Sciences and Health Sciences.

Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electrical engineering and computer science for the ongoing development of Information and Communication Technology.

Faculty of Engineering Technology (ET). The focus at this faculty is on Civil Engineering, Industrial Design and Mechanical Engineering.

Fraunhofer Project Center at the University of Twente enables industrial progress through technology development and training, and by driving industrial innovation and growth for the benefit of their customers.

The Faculty of Geo-Information Science and Earth Observation (ITC) aims to enable society to effectively develop and use geo-information and earth observation knowledge and technology for agricultural and environmental sustainability.

Faculty of Applied Sciences (TNW, Science & Technology). The focus at this faculty is on 3 domains, namely Chemistry, Health and Physics.